Research shows that common acne medications Accutane and Roaccutane can double the risk of eye infections. A study involving nearly 15,000 teenagers found that the incidence of eye inflammation was twice as high among those taking Accutane or Roaccutane. A common side effect of these medications is very dry skin, and researchers believe it is natural for these drugs to also affect the lubrication of the eyelids, especially the glands along the eyelid. Over time, this can lead to corneal degeneration.
Inbal Goldshtein. Ocular Adverse Effects of Systemic Treatment With Isotretinoin. Archives of Dermatology, 2012; 1 DOI: 10.1001/archdermatol.2012.352